en تخصصي Special Original articles <div style="text-align: justify;"><strong><em>Introduction: </em></strong>Particular Mineral (PM) less than 2.5 (PM_2.5) is considered as one of the most important pollutants with major health effects. Therefore, the aim of this study was to evaluate spatial and temporal variations of PM_2.5 concentrate and air quality in Isfahan city in 2016<strong>.</strong><br> <strong><em>Materials and Methods:</em></strong> In this cross-sectional study, spatial and temporal changes in PM_2.5 concentrations were evaluated. The concentrations of PM_2.5in 6 stations in Isfahan were measured. Data were analyzed using Excel and SPSS software.<br> <strong><em>Results:</em></strong> The results of the study showed that PM_2.5 concentrations were higher in warm months than in cold months, and also in the early days of the week&#39;s PM_2.5 concentrations were higher than the weekends. The total average of concentration of PM_2.5 in Isfahan was 29.87 &plusmn; 10.9 &mu;g/m³. City of Isfahan was healthy for 296 days and was in an unhealthy condition for 70 days. Furthermore, concentration of PM_2.5 was higher in the central parts of Isfahan.<br> <strong><em>Conclusion:</em></strong> The present study showed that in most days and months of the year, the concentration of PM_2.5in Isfahan was higher than the standard limit of World Health Organization (25 &mu;g/m³), and PM_2.5 concentrations mean in the cold season was higher than the&nbsp; hot season. It seems that the growth, control and the management of this pollutant is essential for citizens&#39; health and reduction of unhealthy effects.</div> Isfahan City, Air Pollution, PM2.5. 685 693 http://jehsd.ssu.ac.ir/browse.php?a_code=A-10-1-101&slc_lang=en&sid=1 Hossein Jadidi 0000-0002-1544-710X No Student Research Committee, Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran. Abbas Shahsavani 0000-0003-3805-6256 No Department of Environmental Health, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Behzad Mahaki Behzad.Mahaki@gmail.com 0000-0001-7062-6971 Yes Department of Biostatistics, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.